TABLE 2.
Infection of cells with HIV-1 molecular clones
| Molecular clonea | Fold increase in RT activity after infection ofb:
|
||||||
|---|---|---|---|---|---|---|---|
| Donor PBMC
|
Donor MΦ
|
T-cell line:
|
|||||
| 1 | 2 | 1 | 2 | MT-2 | Jurkat | Hut78 | |
| A/BM9 | 38 | — | — | — | 98 | 357 | — |
| B/BM1 | — | 19 | — | — | — | — | — |
| B/BM4 | — | 21 | — | — | — | — | — |
| B/BM8 | 59 | — | — | — | 192 | 415 | 26 |
| C/BM6 | 57 | 11 | 29 | 9.8 | — | — | — |
| C/BM11 | 56 | 7.6 | 22 | 17 | — | — | — |
| D/BM12 | — | 25 | — | — | — | — | — |
| D/BM13 | 33 | 22 | — | — | — | — | — |
| J/BM2 | — | — | — | — | — | — | — |
| J/BM11 | — | 16 | — | — | — | — | — |
| K/BM15 | 66 | 10 | 150 | 64 | — | — | — |
| J/Bld47 | 38 | 12 | — | — | 234 | — | — |
| K/Bld1 | 55 | 9.5 | 6.6 | 5.2 | — | — | — |
a
HIV-1 molecular clones from TP patients are underlined.
b
Numerical values represent the fold increase in reverse transcriptase (RT) activity above the background, and dashes represent background levels of RT activity (3 × 103 to 5 × 103 cpm/ml). The time points shown are at the peak of RT activity. MΦ, primary macrophages.