Table 3.

Results of the reverse MR study.

Disease	SNPs (n)	OR (95%CI)	p-value
Alzheimer’s disease
Inverse variance weighted	18	1.003 (0.993–1.012)	0.567
MR Egger regression	18	1.003 (0.990–1.017)	0.654
Weighted median	18	1.003 (0.993–1.013)	0.551
Maximum likelihood	18	1.003 (0.996–1.010)	0.443
Parkinson’s disease
Inverse variance weighted	22	1.019 (1.001–1.036)	0.036
MR Egger regression	22	1.015 (0.982–1.048)	0.120
Weighted median	22	1.014 (0.999–1.027)	0.054
Maximum likelihood	22	1.019 (1.010–1.028)	<0.001*
Ischemic stroke
Inverse variance weighted	7	0.978 (0.944–1.014)	0.241
MR Egger regression	7	0.916 (0.685–1.223)	0.578
Weighted median	7	0.982 (0.943–1.022)	0.375
Maximum likelihood	7	0.978 (0.948–1.009)	0.162
Intracerebral hemorrhage
Inverse variance weighted	1	NA	NA
MR Egger regression	1	NA	NA
Weighted median	1	NA	NA
Maximum likelihood	1	NA	NA
Cerebral aneurysm
Inverse variance weighted	0	NA	NA
MR Egger regression	0	NA	NA
Weighted median	0	NA	NA
Maximum likelihood	0	NA	NA
Subarachnoid hemorrhage
Inverse variance weighted	0	NA	NA
MR Egger regression	0	NA	NA
Weighted median	0	NA	NA
Maximum likelihood	0	NA	NA
Epilepsy
Inverse variance weighted	0	NA	NA
MR Egger regression	0	NA	NA
Weighted median	0	NA	NA
Maximum likelihood	0	NA	NA

OR, odds ratio; CI, confidence interval; MR, Mendelian randomization; SNPs, single nucleotide polymorphisms; NA, Not available. *statistically significant difference with a p-value less than 0.05 (p < 0.05).