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. 2023 Aug 8;2023(8):CD010872. doi: 10.1002/14651858.CD010872.pub2

1. Examples of fibrin‐based haemostatic agents and their main components.

Product name Fibrinogen concentration (mg/mL) Thrombin concentration (IU/mL) Factor XIII concentration (U/mL) Antifibrinolytic agent
Beriplast P (CSL Behring, Germany) 90 500 60 Bovine aprotinin: 1000 KIU/mL
Biocol (LFB, France) 127 558 11 Bovine aprotinin: 3000 KIU/mL
Bolheal (Kaketsuken Pharmaceutical, Japan) 80 250 75 Bovine aprotinin: 1000 KIU/mL
Evicel – formerly Crosseal® (Omrix Biopharmaceuticals, Israel) 70 1000 None None
Quixil (Omrix Biopharmaceuticals, Israel) 50 1000 None Tranexamic acid: 85 to 105 mg/mL
Tachosil (Nycomed, Switzerland) 5.5a 2.0b None None
Tisseel (Baxter, Austria) 90 500 30 Bovine aprotinin: 3000 KIU/mL

amg/cm2.
bIU/cm2.
KIU: kallikrein inhibitor units.