Figueras 2007.

Study characteristics
Methods	Study design: randomised trial Follow‐up: 6‐months after surgery
Participants	Setting: single‐centre study in Spain Number randomised: 300 participants
Interventions	Intervention: fibrin glue (n = 150) 5 mL of Tissucol (Baxter‐Inmuno, Vienna, Austria) was applied in aerosol form on the raw surface of the liver. An absorbable collagen sponge (Johnson & Johnson) was also applied with manual pressure, after spraying the fibrin glue. Control: no intervention (n = 150) Neither the fibrin sealant nor the collagen sponge was used.
Outcomes	Primary outcomes Mean total blood loss Percentage of participants with intra‐ or postoperative transfusion Mean number packed red cells transfused Percentage with intraoperative fresh frozen plasma transfusion Percentage with intraoperative platelet transfusion Secondary outcomes Mean number of days postoperative drainage Mean overall drain volume Percentage of reoperations Percentage of biliary fistula, abdominal abscess or abdominal bleeding Percentage requiring percutaneous drainage of collection Mortality
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomisation process not specified.
Allocation concealment (selection bias)	Unclear risk	Method of concealment, if used, not specified.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Blinding of participants and personnel not specified.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Blinding of participants and personnel not specified.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Randomised patients analysed. No dropouts/exclusions after randomisation reported.
Selective reporting (reporting bias)	Unclear risk	No protocol published.
Other bias	Low risk	Funding from academic source, with no commercial interest. No other bias identified.