Fischer 2011.

Study characteristics
Methods	Study design: randomised trial Follow‐up: not reported
Participants	Setting: European multicentre trial (10 centres) Number randomised: 121 (2 participants excluded postrandomisation)
Interventions	Intervention: TachoSil (n = 60) TachoSil, a sterile, ready‐to‐ use, absorbable surgical patch consisting of an equine collagen sponge coated with human fibrinogen and human thrombin measuring 9.5 x 4.8 x 0.5 cm, was applied on the resection surfaces after being moistened with physiological saline. The yellow‐coated side (active side) of the patch was held against the resection surface for 3 minutes to ensure uniform contact. The resection site(s) had to be covered at least 1 cm beyond its margin, and if > 1 patch was needed, they had to overlap. TachoSil treatment could be repeated after 5 to 8 minutes. Control: argon beam coagulator (ABC: n = 59) Management of bleeding with the ABC was done according to the routine of the centres. All hepatic resection areas were treated, and treatment was repeated if haemostasis was not achieved within 5 minutes. The duration and number of treatments were recorded. Co‐interventions: escape treatment was applied if haemostasis was not obtained within 10 minutes after the application of study treatment. No specific escape treatment was defined, but was chosen according to local protocols
Outcomes	Primary outcome: time to haemostasis Secondary outcomes Total drainage volume Total postoperative duration of drainage Drain fluid haemoglobin and bilirubin Measurement (with ultrasound) volume of blood/liquid at resection surface
Notes	2 participants were excluded postrandomisation due to incorrect randomisation. 6 participants discontinued the study due to adverse events (2 in TachoSil group, 4 in ABC group).
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Centralised telephone randomisation system.
Allocation concealment (selection bias)	Low risk	Centralised telephone randomisation system.
Blinding of participants and personnel (performance bias) All outcomes	High risk	Assessors not blinded to allocation.
Blinding of outcome assessment (detection bias) All outcomes	High risk	Participants and personnel not blinded.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No follow‐up protocol specified.
Selective reporting (reporting bias)	Low risk	All relevant outcomes reported.
Other bias	Low risk	No other bias identified.