Table 2. Semi-quantitative analysis of targeted marker expression IPF and COP.

PMC markers	Honeycombing in IPF or epithelial cells surrounding fibrous tufts in COP			Fibroblastic foci in IPF or fibrotic area in COP
	IPF	COP	P value	IPF	COP	P value
LRRN4	2.41 ± 0.59	0.33 ± 0.50	< 0.001	2.30 ± 0.73	0.55 ± 0.52	< 0.001
UPK3B	1.00 ± 0.72	0.55 ± 0.66	0.111	0.45 ± 0.51	0.77 ± 0.66	0.157
CCL18	1.75 ± 1.07	0.77 ± 0.97	0.027	0.35 ± 0.87	0.0 ± 0.0	0.245
Laminin-5	1.35 ± 0.58	1.77 ± 0.83	0.123	0.85 ± 0.48	1.66 ± 0.86	< 0.003

Data are presented as mean expression score ± standard deviation.

IPF = idiopathic pulmonary fibrosis, COP = cryptogenic organizing pneumonia, PMC = pleural mesothelial cell, LRRN4 = leucine rich repeat neuronal 4, UPK3B = uroplakin 3b, CCL18 = CC-chemokine ligand 18.