Table 2.
Clinical, dermoscopic and histopathological features of SFS.
| Clinical Features | Dermoscopy | Histopathology | |
|---|---|---|---|
| Dermatophytes | Follicular micropapule. | Comma, broken and corkscrew hair, black dots and pustules with or without trapped hair. | Superficial and deep mixed perifollicular infiltrate. Positive PAS staining. |
| Candida | From small pustules to painful papules, nodules and pustules with the presence of itching. | Multiple whitish pinpoint pustules, scattered throughout the scalp. Peripheral erythematous halo with small dilated capillaries. |
Dense perifollicular mixed-type infiltrate, edema, abscesses at the follicular epithelium and PAS-positive staining. |
| Malassezia | Folliculitis with small whitish scales on the scalp, erythematous-desquamative plaques with greasy appearance and seborrhea with greasy and opaque hair. | Furfuraceous scales, arborized vascular and atypical reticular dilatations, small whitish folliculitis, centered by the hair and a small crust secondary to itching. | Mild to moderate lymphocytic inflammatory infiltrate at the infundibular, peri-infundibular and peri-isthmic level, mild fibroplasia, abscesses, dilation of the infundibulum with laminated orthokeratosis and focal parakeratosis of the epidermis. |
| Bacteria | A single lesion with a tuft of hair. Yellowish-whitish pustule with perifollicular erythema, yellow-brownish crusts, painful perifollicular papular lesions with peripheral erythema. | A crusty thickened exudative lesion, yellowish in color, with a central tuft and peripheral erythema; brownish yellow background with an aflegmasic alopecia, atrophy, and absence of follicular openings. | Collection of neutrophils and bacteria in the epidermis with dilated vessels, edema, and mild-moderate mixed type -infiltrate in the papillary and middle dermis. |
| Herpes Zoster | Multiple vesicles and subsequent pustules following the innervation, with neuritis of the scalp. | Herpetic polymorphism: vesicles, pustules and crusts at the same time and peripheral erythema with numerous dilated and superficial capillaries, scabs and scarring lesions. | Intraepidermal vesicles containing multinucleated keratinocytes with a nucleus of grayish color, marginal chromatin, ballooning cytoplasm and acantholysis. A moderate-dense perivascular and interstitial inflammatory infiltrate of mixed-type fibrosis and destruction of the adnexal structures. |
| Pox virus | Hemispherical and roundish papules, in pale-pink color, 2–3 mm in diameter, with a central navel and a smooth regular surface. | Central umbilicated papule surrounded by yellowish-white polylobed amorphous structures. Crown vessels known as “red corona” emerge from the periphery of the lesion and radiate towards the center, rarely crossing each other. | Rounded basophilic bodies present among the keratinocytes are observed, grouped in a “crater” and in the infundibular hyperplastic areas of the granular and spinous layer of the epidermis. |
| Acneiform Eruption | Papules, pustules or follicular crusts on erythematous skin, pain with possible bleeding or leakage of pus. | Central pustular lesions, intensely erythematous with dilated capillaries in the periphery, crusts of variable colors from intense red to yellowish-brown, dilated vessels with a lattice appearance throughout the scalp. | Suppurative folliculitis in the superficial dermis with a neutrophilic inflammatory infiltrate, dilated sebaceous glands and hyperkeratinization of the intrainfundibular epithelium and retention of lamellae, plugs. |
| Rosacea | Diffuse erythema of the scalp with small dry scales, painful flat erythematous round lesions, and facial involvement. | Branching vessels with a yellowish central area that turns brownish over time. | Vasodilation of the vessels of the subpapillary plexus and a polymorphic inflammatory infiltrate, non-caseous granulomatous infiltrate in the perifollicular and perivascular areas, and the presence of Demodex Folliculorum. |
| Ofuji syndrome | Plaque of small erythematous-edematous, sterile pustules in seborrheic areas. | Central folliculitis with dilated capillaries in the periphery and yellowish crust. | Massive mixed-type inflammatory infiltrates, microabscesses, epithelial necrosis and intercellular edema. |