Fig. 4.

Effect of fisetin on some genes or enzyme. (1) Targeting at urokinase secretion and tubule formation of p38 cells, exhibiting the effect of anti-angiogensis and activation of NF-κB. (2) Inhibition of the expression of MAPK/P13K/AKT/JNK, promoter activity and uPA, MMPS and YB = 1 cell migration/invasion as well as EMT. Moreover, fisetin activated ERK1/2 that inhibited the ADAM9. “↓” indicates “stimulate” “⊥” indicates “inhibit”; solid line represents the action directly; dotted line represents the action through several processes. Abbreviations: p38, mitogen-activated protein kinases; NF-κB, Nuclear factor kappa light chain enhancer of activated B cells; uPA, a serine protease present in humans and other animals; The JNK, proteins belong to a class of proteins known as the MAPK, family of mitogen-activated protein kinase. They relay, amplify, and integrate signals from a diverse range of stimuli, both intra- and extracellular. ERK1/2: extracellular signal regulated protein kinase; AKT, protein Kinase-B.