Extended Data Fig. 9. Sst44 cell activity increases after learning to adjust to a within-trial change in cue and reward location.

a, On 50% of trials, we changed the cue at the halfway point from black to white or white to black, along with the reward location, such that the mouse was rewarded based on the second cue. The change in cue was visible as the mouse approached it. b–e, Activity and behaviour as the mouse passed the halfway point during cue switch and control trials, split based on behavioural performance (low accuracy < 80% correct, high accuracy > 80% correct). Wilcoxon rank-sum test across trials, Sst44 cell activity solid vs dashed line, activity averaged over 0 to 1 s relative to −1 to 0 s: p < 1e-10 (b–c), p = 2e-4 (d), p = 0.997 (e). Wilcoxon signed-rank test across trials, activity on high accuracy trials relative to mean activity on low accuracy trials, averaged over 0 to 1 s, Sst44 vs other cell types: p < 1e-10 (b–d), Sst44 vs Sst: p = 2e-4 (e), Sst44 vs Non-Sst: p = 0.7 (e). Mean and bootstrapped 95% confidence intervals are shown. 7 mice, 45 sessions.