Extended Data Fig. 2. Netrin-1 blockade impacts tumor growth in a preclinical mouse model.
a, Percentage of mice treated with control (n = 12) or NP137 (n = 16), showing hyperplasia or Adenocarcinoma (ADK) of the endometrium. *** P < 0.001 by Chi-square test and Fischer’s exact test. b, Quantification of the thyroid weight in CreERT2−/− mice (n = 10) or after Pten deletion (Tamoxifen injection) in CreERT2+/−x Pten f/f mice treated with control (n = 13) or NP137 (n = 11). Bars are mean values mean ± s.e.m., *** P < 0.001 against CreERT2−/−; ## P = 0.015 NP137 against control by Mann-Whitney two-sided. c, Representative images of the thyroids in panel b. d, Representative images of H&E staining of thyroid from mice sacrificed in weeks 5-6 after tamoxifen injection. Scale bar represented by a line, (100 µm) similar observations have been done on the full cohort. e, Percentage of mice showing mild or severe hyperplasia of the thyroid in mice treated (n = 16) or not with NP137 (n = 12). *** P < 0.001 by Chi-square test and Fischer’s exact test.