Extended Data Fig. 3. STING blockade decreases proinflammatory cytokine production in human adipose tissue.
a, Schematic of omental adipose tissue explants studies. b, ELISA measurement, from individual patients, of IL-6 (n = 11), IL-8 (n = 11) and MCP-1 (n = 6) in the conditioned medium of tissue explants. c,d, mRNA expression levels of proinflammatory and interferon-stimulated genes (c) and adipose tissue functional genes (d), normalized per patient (n = 6) to the DMSO control condition. e, Representative images of senescence-associated β-galactosidase (SA-β-GAL) staining of omental fat tissue (n = 1 tissue, represents n = 11 patients), cleared with RapiClear. Arrows indicate examples of SA-β-GAL+ cells. Scale bars, 100 μm. Data are mean ± s.e.m. P values were obtained with two-sided paired ratio Student’s t-test (b–d). D + Q; senolytic drug combination Dasatinib and Quercetin.