Fig. 3.

NLRP3 agonist promotes abscopal responses. a, b tumor growth curves of secondary tumors of 12Gy in 344SQ-P (a) and in 344SQ-R (b). The lung metastases counts (normalized by the day of sacrifice) of mice that received different treatments in 344SQ-P (c) and 344SQ-R (d). Multiple serum pro-inflammatory cytokines in different treatment groups from 344SQ-P (e) and 344SQ-R (f) models. Two-way analysis of variance with multiple comparisons was used to analyze the tumor growth curves, and unpaired t test was used in comparison of lung metastases and cytokines. Data are presented as mean values ± SD. *P < 0.05, **P < 0.01; ****P < 0.0001; ns, not significant