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. 2023 Aug 9;9:290. doi: 10.1038/s41420-023-01588-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — After single intranasal administrations, time-dependent 11C7 concentration changes were followed in the mouse CNS by capture ELISA using rat Nogo-A delta 20 fragment as a bait. A The level of 11C7 quickly increased in rostral CNS structures close to the site of administration, such as the olfactory bulb. In addition, 11C7 was detectable in spinal cord segments as early as 0.5 h after olfactory mucosa-targeted application, suggesting fast and widespread CNS distribution of the antibody using this route of administration. B 11C7 kinetic analysis suggests a decline starting 3 or 4 h post administration and confirmed at 24 h.