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. 2023 Aug 9;9:290. doi: 10.1038/s41420-023-01588-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Myelin was examined in the cervical, thoracic and lumbar segments on transverse sections of spinal cords stained with LFB-PAS, 30 days after MOG-induced EAE. A LFB-PAS stainings revealed a predominant demyelination in the lumbar spinal cord of mice treated with control IgG. In contrast, LFB-free areas were smaller in mice treated with 11C7. B Quantitatively, the % of demyelination was statistically lower in the lumbar spinal cord of mice receiving 11C7 than in control littermates (*P < 0.05; NS not significant). C The % of demyelination in lumbar spinal cord correlated with the EAE clinical scores of control IgG-injected mice (Pearson r = 0.9635; **P < 0.01). For quantitative analysis, three sections were used per animal in each segment, as shown in the top cartoon. Scale bars: A = 500 μm, close-ups= 200 μm.