Fig. 4. Hematologic effects of hypofractionated stereotactic ablative radiotherapy (SART) to the pelvis.

a Blood cell counts at the indicated number of days or weeks after completion of 5 fractions of radiation delivered on an every-other-day schedule or sham treatment. For females n = 3–12 for 2-day time point and n = 3 for all other time points (except n = 2 for 9 Gy x 5 group at 8-week time point due to 1 treatment-related death). For males n = 6–9 for 2-day time point and n = 3 for all other time points. Females with increased neutrophil counts at 8 weeks had chronic intestinal injury and inflammation. b Lymphocyte subtype counts determined by multiplexed flow cytometry in whole blood 2 days after completion of 5 fractions of radiation or sham treatment as indicated. Mean ±SD. Data are normalized to the mean of untreated controls. c Lymphocyte subtypes as a percent of total leukocytes 2 days after completion of radiation in females. Mean ±SD. d Lymphocyte subtypes as a percent of total leukocytes 2 days after completion of radiation in males. Mean ± SD. For all panels *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 by unpaired 2-tailed t test.