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. 2023 Aug 9;13:12888. doi: 10.1038/s41598-023-40051-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pathways altered by low-dose radiation. (A) Clustering heatmap of altered “canonical pathways”. IPA analysis revealed 212 canonical pathways that differed by more than 2–log (p value) in expression in irradiated cells compared to nonirradiated cells according to the RNA-seq data. Among them, 13 with high Z scores (cut-off, 2.5) were clustered. (B) Clustering heatmap of altered “Diseases and functions.” Comparison between the effects of radiation doses (0, 30, or 180 mGy) on days 6, 10, 17, and 35. The IPA-calculated p value and Z score for each “functions and diseases” pathway differed by > 2 of –log (p value) in RNA-seq. Clustering of the eight pathways that had high Z scores (cut-off, 3.0) is shown.