Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 9;13:12888. doi: 10.1038/s41598-023-40051-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Expression of retinal and neural development-related genes on Day 35. Cells were exposed to 0, 30, or 180 mGy of radiation from days 4 to 5 of development. RNA was extracted on day 35. Each sample includes 6 to 12 EBs. (A) Main four TFs for RGC development. Altered expression of PAX6, ATOH7, POU4F2, and HES1 by radiation was found. (B) Early-stage retinal development-related genes. Altered expression of POU5F1, TP53, CDKN1A, NRG1, NEFM, DLK1, and SIX3 was found. (C) Late-stage retinal development-related genes. Altered time-course expression of VSX2, DMD, PAX2, COL4A5, NEFM, and KLF7 was found. (D) Neuronal development-related genes. VIM, JUN and PARD3 are members of the Rho family of GTPases and are involved in neuronal development. After 180 mGy of irradiation, their expression was upregulated on day 35. The mean FPKM and average of the absolute deviations detected by RNA-seq three times are shown (n = 3). Error bar: average absolute deviation, *p < 0.05, **p < 0.01 (Student’s paired t test).