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. 2023 Jun 24;146(3):395–414. doi: 10.1007/s00401-023-02604-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — MAPT transcripts in neurons and glia revealed by light microscopy RNAscope in a control case. a MAPT transcripts (red) in neurons in the frontal cortex are observed individually or in small clusters of transcripts. MAPT transcripts were found in both the nucleus and cytoplasm. Neurons contain RBFOX3 transcripts (blue), the cell-specific marker. Dashed box in (a) shows a pyramidal neuron at higher magnification. b MAPT (red) and RBFOX3 (blue) transcripts in cerebellar granular neurons. c MAPT transcripts (red) in oligodendrocytes were commonly located in the nucleus, shown with oligodendrocyte-specific transcripts, Olig2 (blue). d MAPT transcripts (red) in astrocytes were also commonly found in the nucleus, shown with astrocyte-specific transcripts, ALDH1L1 (blue). Scale bar in (a) represents 30 μm for (a) (inset 50 μm), 50 μm for (b), 10 μm for (c) and 8 μm for (d)