Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 24;146(3):395–414. doi: 10.1007/s00401-023-02604-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — Fluorescent RNAscope combined with phosphorylated tau (AT8) immunohistochemistry in oligodendrocytic and astrocytic inclusions in progressive supranuclear palsy (PSP). Each horizontal set represents confocal images taken from the same field of view showing AT8-immunostaining (green), MAPT transcripts (red) and the oligodendrocyte-specific Olig2 or astrocyte-specific ALDH1L1 (yellow) transcripts, DAPI (blue), and the merge image. a Coiled bodies (arrowheads) and neurons (arrow) without neurofibrillary tangles in the frontal cortex. Note the higher density of MAPT transcripts in neurons compared with oligodendrocytes. White box in panel (a) is enlarged in panel (b). b, c Oligodendrocytes with (arrowheads) and without (arrows) tau-immunopositive inclusions show variation in MAPT transcript density, and an enlarged image of an oligodendrocytic coiled body in panel (d). e Tufted astrocyte (arrowhead) in the frontal cortex. f, g Enlarged view of tufted astrocytes, which show variation in the density of MAPT transcripts. Note the higher density of MAPT transcripts in neurons (arrow) compared with the tufted astrocyte (arrowhead) in panel (f). Scale bar in (a) represents 20 μm for (a), 10 μm for (c, d), 5 μm for (d), 30 μm for (e), 12 μm for (f), and 6 μm for (g)