. 2023 Aug 9;19(8):72. doi: 10.1007/s11306-023-02035-5

Table 3.

Spearman’s rank correlation coefficients of BMI, LDL and triglycerides with empiric and estimated log SI and log HOMA-IR. using inverse normal transformation of the metabolites

Variable	Training	Testing	BMI^a	LDL^b	Triglycerides^b
Empiric SI		SA	− 0.58, < 0.001	− 0.05, 0.15	− 0.43, < 0.001
Empiric SI		AA	− 0.53, < 0.001	− 0.28, < 0.001	− 0.34, < 0.001
Estimated SI	SLV	SA	− 0.66, < 0.001	− 0.03, 0.11	− 0.49, < 0.001
(LASSO)	MA	AA	− 0.59, < 0.001	− 0.24, < 0.001	− 0.46, < 0.001
Estimated SI	SLV	SA	− 0.68, < 0.001	− 0.01, 0.23	− 0.47, < 0.001
(Elastic Net)	MA	AA	− 0.58, < 0.001	− 0.23, < 0.001	− 0.45, < 0.001
Empiric HOMA-IR		SA	0.59, < 0.001	0.06, 0.06	0.35, < 0.001
Empiric HOMA-IR		AA	0.50, < 0.001	0.16, < 0.001	0.29, < 0.001
Estimated HOMA-IR	SLV	SA	0.63, < 0.001	0.05, 0.090	0.45, < 0.001
(LASSO)	MA	AA	0.55, < 0.001	0.26, < 0.001	0.40, < 0.001
Estimated HOMA-IR	SLV	SA	0.59, < 0.001	0.06, 0.027	0.42, < 0.001
(Elastic Net)	MA	AA	0.55, < 0.001	0.25, < 0.001	0.40, < 0.001

SLV San Luis Valley; SA San Antonio; MA Mexican American; AA African American. ^aEstimated SI or HOMA-IR was calculated based on Model 2 (estimated based on age, gender, and metabolites), ^bestimated SI or HOMA-IR was calculated based on Model 3 (estimated based on age, gender, BMI, and metabolites)