Table 3.
Cryptic exon detection for STMN2 and KALRN in a deeply sequenced subject (C9-FTD 4)
| Subject: C9-FTD 4 | Number of cells sequenced | Baseline Sequencing | Deep Sequencing | ||||
|---|---|---|---|---|---|---|---|
| STMN2 CE junctions | KALRN CE junctions | CE detected/ Cells in cluster | STMN2 CE junctions | KALRN CE junctions | CE detected/ Cells in cluster | ||
| L2–L3 Intratelencephalic | 2,830 | 8 | 6 | 0.005 | 83 | 53 | 0.048 |
| L3–L5 Intratelencephalic—Type 1 | 582 | 1 | 0 | 0.002 | 10 | 0 | 0.017 |
| L3–L5 Intratelencephalic—Type 2 | 901 | 13 | 0 | 0.014 | 93 | 6 | 0.110 |
| L5-L6 Near Projecting | 169 | 0 | 0 | 0.000 | 0 | 0 | 0.000 |
| L5 Extratelencephalic | 37 | 6 | 0 | 0.162 | 24 | 0 | 0.649 |
| L6 Intratelencephalic—Type 1 | 674 | 4 | 0 | 0.006 | 36 | 0 | 0.053 |
| L6 Intratelencephalic—Type 2 | 178 | 0 | 0 | 0.000 | 0 | 0 | 0.000 |
| L6 Corticothalamic/L6B | 315 | 0 | 0 | 0.000 | 0 | 0 | 0.000 |
| Somatostatin Interneurons | 876 | 0 | 0 | 0.000 | 0 | 0 | 0.000 |
| Parvalbumin interneurons | 94 | 0 | 0 | 0.000 | 0 | 0 | 0.000 |
| VIP Interneurons | 498 | 0 | 0 | 0.000 | 0 | 0 | 0.000 |
| SV2C LAMP5 Interneurons | 276 | 0 | 0 | 0.000 | 0 | 0 | 0.000 |
| Astrocytes | 1644 | 1 | 0 | 0.001 | 6 | 0 | 0.004 |
| Microglia | 267 | 0 | 0 | 0.000 | 0 | 0 | 0.000 |
| Oligodendrocytes | 3738 | 0 | 0 | 0.000 | 0 | 0 | 0.000 |
| Total | 13,079 | 33 | 6 | 0.003 | 252 | 59 | 0.024 |