Table 1. Clinical features and main causative agents of chronic DILI8,22,25.

Clinical features of DILI	Causative agents
Fatty liver	5-fluorouracil, diltiazem, cortisone, vitamin A, interferon, NSAIDs, intravenous valproic acid, intravenous tetracycline, tamoxifen, amiodarone, methotrexate, antiretroviral
Nodular regenerative hyperplasia	6-mercaptopurine, azathioprine, vitamin A, platinum, antiretroviral drugs
Hepatocellular adenoma	Anabolic steroids, oral contraceptives
Drug-induced autoimmune hepatitis	Nitrofurantoin, minocycline, hydralazine, methyldopa, interferon, statins, biologics (antibody drugs)
Vanishing bile duct syndrome	Amoxicillin/clavulanic acid, fluoroquinolones, sulfamethoxazole, azithromycin, carbamazepine, lamotrigine, chlorpromazine, allopurinol, demozolomide, ibuprofen
Liver cirrhosis	Amiodarone, methotrexate, vitamin A, valproic acid

DILI, drug-induced liver injury; NSAIDs, nonsteroidal anti-inflammatory drugs.