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. 2023 May 12;11(5):1246–1255. doi: 10.14218/JCTH.2022.00122

Fig. 2. Effects of liver-derived secretory factors on targeted cells and the underlying mechanisms.

Fig. 2

These factors mainly act on VECs, VSMCs, CMs, FBs, Mo/Mϕ and platelets, and the effects and mechanisms presented in the studies are summarized. Parts of the figure were obtained from Servier Medical Art (https://smart.servier.com/). Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License. CMs, cardiomyocytes; EVs, extracellular vesicles; FBs, fibroblasts; Mo/Mϕ, monocytes/macrophages; TMAO, trimethylamine N-oxide; VECs, vascular endothelial cells; VSMCs, vascular smooth muscle cells.