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. 2023 May 31;11(5):1201–1211. doi: 10.14218/JCTH.2023.00029

Fig. 2. Etiology of increased hepatic vascular resistance in NAFLD.

Fig. 2

Schematic illustration of extraluminal and intraluminal causes of impaired sinusoidal flow between the portal tract and the pericentral region that result in increased hepatic vascular resistance, which is the primary factor in the development of sinusoidal portal hypertension in advanced chronic liver disease. Barriers to sinusoidal flow may also be classified as structural and functional factors. Please see details in the main text. NAFLD, nonalcoholic fatty liver disease.