Fig. 4. Sinusoidal pressure-liver fibrosis paradigm.

Schematic illustration of the bidirectional relationship between subclinical portal hypertension and fibrosis, implicating the contribution of mechanocrine signals, such as increased sinusoidal pressure, in the development and progression of fibrosis through cell-cell communication and self-amplification mechanisms, ultimately resulting in clinically significant portal hypertension. Further research is needed to explore the cellular and molecular details of this process.