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Tumor microenvironmental influences on CSCs. The tumor‐associated stroma has an important role in the regulation of cancer stemness in glioma. Regulation of CSCs by their niche occurs through cell–matrix interactions and cell–cell interactions. The most prominent players in glioma CSC–stroma interactions include hypoxia, acidosis and extracellular matrix (ECM) remodeling; cellular components include endothelial cells.
