Fig. 5.

Pt NPs protect PRs from light-induced oxidative damage. (A) Pt NPs reduced TUNEL⁺ cells in ONL of the retina. Scale bar, 20 μm. (B) Zoomed view of the region inside the box in the upper figures (red, TUNEL positive cells; blue, DAPI for nucleus). Scale bar, 20 μm. (C) Representative images of OCT for each group. The red lines indicated the thickness of ONL. (D) Schematic diagram of the method to measure the thickness of the ONL. (E) The thickness of the ONL at each position was plotted. ONL, outer nuclear layer. ON, optic nerve. LIRD mice that post-treated with vehicle were names as vehicle. Data are expressed as the mean ± SEM, n ≧ 10. One-way ANOVA were used for comparisons with vehicle. #p < 0.0001; ***p < 0.001; **p < 0.01. LIRD, light-induced retinal degeneration.