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. 2023 Aug 1;65:102836. doi: 10.1016/j.redox.2023.102836

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 8 — Important pathways and genes for retina survival in the Pt NPs group. (A) Illustration of mechanism for this study. In the vehicle group, cytotoxic ROS induced by intense light caused retinal degeneration. In the Pt NPs group, cytotoxic ROS was reduced by Pt NPs, activating FoxO pathway to regulate downstream pathway. (B) The normalization of RPKM for the genes that enriched on pathway, based on the result of RNA sequencing. (C) The mRNA expression of 3 key genes of the FoxO pathway. (D) The mRNA expression of 3 key genes of the pentose phosphate pathway. (E) The mRNA expression of 3 key genes of the oxidative stress resistant pathway. Four retinas from different mouse belonging to the same group were pooled and considered as one sample, and each group had 3 replicate samples (n = 3). Data are expressed as the mean ± SD. One-way ANOVA were used for comparisons with vehicle. ***p < 0.001; **p < 0.01; *p < 0.05.