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Multiple cellular factors bind to the CBP TRAM and can be inhibited by an E1A FPESLIL-containing peptide. (A) p53, E2F, and TFIIB all bind to CBP amino acids 1808 to 1826, containing the TRAM. Binding can be inhibited by competition with the wild-type (WT) E1A peptide but not the Mut 2 (Mut) E1A peptide. −, no competitor. (B) Alignment of adenovirus E1A, p53, and E2F sequences showing the conservation (boldface) of FXE/DXXXL residues implicated in the interaction with the CBP TRAM.
