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. 2023 Jun 30;12(7):1436–1444. doi: 10.21037/tlcr-23-10

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2023 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Cumulative incidence of CNS progression (probability) in patients with ROS1- and ALK-positive NSCLC during crizotinib treatment. (A) Cumulative incidence of CNS progression in all patients. (B) Cumulative incidence of CNS progression in patients without brain metastasis at the time of crizotinib initiation. ROS1, C-ros oncogene 1; ALK, anaplastic lymphoma kinase; CNS, central nervous system; NSCLC, non-small cell lung cancer.