Regenerative injectable fillers approved in the United States.

Products	Manufacturer	Time of approval by FDA	Raw material	Diameter (μm)	Base solution	Lidocaine	Needle	Skin test	Indications	Storage (°C)	Duration (years)
Sculptra	Galderma	2004	PLLA microspheres	40–63	CMC, mannitol	Yes	25G	No	Injection into deep dermis for correction of moderate to severe nasolabial folds and other wrinkles/folds in adults with normal immunogenicity	25	1–2
AestheFill	Gegen Biotech	1984	PDLLA microspheres	30–70	CMC	Yes	25G	No	Injection into deep dermis for correction of moderate to severe nasolabial folds and other wrinkles/folds	25	2–3
Ellanse	Sinclair	2009 (CE)	PCL microspheres	25–50	CMC	Yes	27G	No	Subdermal implantation in the face for the lasting correction of wrinkles and facial aging signs or conditions	15–25	1–4
Artecoll	Suneva Medical Inc.	2006	PMMA microspheres	30–50	Bovine collagen solution	Yes	26G	Yes	Injection into the dermal-subcutaneous correction of facial wrinkles/folds and filling of soft tissues	2–8	5–10
Radiesse	Merz Aesthetics	2006	CaHA microspheres	25–45	Sterile water, glycerin, CMC	Yes	26G	No	Injected into the deep dermal subcutaneous for correction of moderate to severe nasolabial folds and wrinkles/folds	25	1–2