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. 2023 Jul 21;22:100741. doi: 10.1016/j.mtbio.2023.100741

Fig. 4.

Fig. 4

Biomaterials enhance angiogenesis to promote bone repair. A) 26SCS-functionalized bimodular scaffolds deliver BMP-2 and VEGF for synergistic osteogenesis and angiogenesis. Reproduced and adapted with permission [133]. Copyright 2020, Elsevier. B) 3D-printed two-factor delivery scaffolds sequentially release DMOG and Sr ions that match the angiogenic and osteogenic processes. Reproduced and adapted with permission [135]. Copyright 2023, American Chemical Society. C) Nanofibrous gelatin-silica hybrid scaffold with the spatiotemporal release of DMOG and bone-forming peptide to enhance angiogenesis and improve bone regeneration. Reproduced and adapted with permission [86]. Copyright 2022, Wiley-VCH GmbH. D) Dynamic DNA hydrogels loaded with black phosphorus nanosheets continuously release VEGF and promote mature vessel growth to induce osteogenesis. Reproduced and adapted with permission [136]. Copyright 2022, Elsevier.