Fig. 7.

pH-responsive biomaterials promote bone repair. A) pH-responsive hydrogel targets selective osteosarcoma cells to release pro-bone repair drugs. Reproduced and adapted with permission [150]. Copyright 2022, American Chemical Society. B) Schematic diagram of the microenvironment of nearby cells affected by the implanted biomaterial. Reproduced and adapted with permission [151]. Copyright 2019, American Chemical Society. C) A nanoscale drug delivery system that reduces pH and can actively build a bone regenerative repair microenvironment. Reproduced and adapted with permission [93]. Copyright 2020, Elsevier. D) Customizable alkaline surface to enhance the osteogenic properties of Ti implants. Reproduced and adapted with permission [94]. Copyright 2021, Elsevier.