Table 1.

The UniDesign-computed energy changes upon the introduction of mutation relative to the triple variant (TM)

Variant	Energy changes relative to the TM variant (UniDesign energy units)
	${\Delta E}_{\mathit{int}}^{R-OMP}$ ($E_{\mathit{int}}^{R-OMP}$)	${\Delta E}_{\mathit{int}}^{S-OMP}$ ($E_{\mathit{int}}^{S-OMP}$)	${\Delta \Delta E}_{\mathit{int}}^{R-S}$	${\Delta E}_{sta}$ ($E_{sta}$)
TM (A82F/F87V/L188Q)	0 (−48.86)	0 (−52.96)	0	0 (−2769.89)
UD1 (TM/L75I)	−0.12 (−48.98)	2.15 (−50.81)	−2.28	2.46 (−2767.43)
UD2 (TM/A264G)	−0.23 (−49.09)	1.05 (−51.91)	−1.28	4.44 (−2765.45)
UD3 (TM/A328V)	−1.27 (−50.13)	0.52 (−52.44)	−1.79	1.46 (−2768.43)