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. 2023 Jul 7;299(8):105023. doi: 10.1016/j.jbc.2023.105023

Figure 3.

Figure 3

Transcriptomic analysis of Pb-treated neuronal culture.A, volcano plots of DEGs identified for mature neurons (Day 45) of (left) 15 ppb vs. 0 ppb and (right) 50 ppb vs. 0 ppb of prior Pb treatment. N = 3 independent differentiations. B, Venn diagram summarized the shared DEGs between 15 ppb and 50 ppb. C, top biological pathways (BP) and cellular compartments (CC) altered by Pb exposure via Gene Ontology analysis with Padj next to each pathway. Standardized mean transcription level of genes regulating (D) calcium homeostasis, (E) 5 mC, (F) H3K27me3, (G) H3K4me3, and (H) genes associated with Alzheimer’s Disease. The heat maps in (E–G) share the same look-up table (LUT). Normalized gene expression was represented as z-score where z-score = ((gene expression of each group) − (mean expression across all groups))/(standard deviation of gene expression across all groups).