Figure 5.

Summary of nitrated proteins implicated in oncology.A, nitrated proteins implicated in oncology include those involved in intracellular signaling, immune surveillance, cytokine pathway stimulation, Damage Associated Molecular Pattern (DAMP) expression, and resistance to chemotherapeutics. Nitration of proteins can serve a regulatory function, and the tyrosine residues that are nitrated in many of these proteins are often the same as those that are tyrosine phosphorylated. Nitration of some inhibit tyrosine phosphorylation to regulate protein activity. B, STAT1 nitration inhibits its phosphorylation and signaling. The interferon (IFN) pathway is essential for immunosurveillance. IFN activates immunosurveillance by phosphorylation at tyrosine (Y701) of the signal transducer and activator of transcription 1-alpha/beta (STAT1). STAT1 phosphorylation at (Y701) is required for translocation to the nucleus to activate transcription of its target genes. Nitration at tyrosine (Y701) inhibits STAT1 phosphorylation, translocation, and activation of transcription.