Table 2.

Precaution and adverse effects of intermittent fasting

Condition	Complications
Type 1 and 2 diabetes mellitus	Paucity of evidence on safety Extra caution such as frequent self-monitoring of capillary glucose required. Continuous glucose monitoring and flash glucose monitoring with alarm systems are now widely available, enabling safe adoption of intermittent fasting.
Anorexia nervosa (study subjects with BMI <25)	Potential worsening of anorexia nervosa and excess weight loss
Amyotrophic lateral sclerosis	Motor neurons may be vulnerable to prolonged fasting. Enhanced neurodegeneration in the inherited form of amyotrophic lateral sclerosis.
Loss of lean body mass	Resistance training required