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. 2023 Aug 10;14:200. doi: 10.1186/s13287-023-03430-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The secretomes of the advanced RCC cells share commonly altered proteins. A DPP4 concentration (left plot) and activity (right plot) in CM from RPTEC and RCC cell lines. B ELISA validation of AREG, CXCL8, EGF, FN1, HEBP1 and MMP1 in CM from RCC cell lines. C The expression of genes encoding cytokines is altered in RCC cell lines. The plots show the results of qPCR analysis. N = 3 independent biological experiments. D The expression of genes encoding cytokines is altered in RCC tumors. The plots show the results of qPCR analysis performed in 100 matched-paired control-tumor samples. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Statistical analysis was performed using one-way ANOVA with Dunnett's multiple comparisons test (A–C), paired t test or Wilcoxon matched pairs test (D)