IVD
|
Intervertebral disc |
IVDD
|
Intervertebral disc degeneration |
RCD
|
Regulated cell death |
ROS
|
Reactive oxygen species |
LBP
|
Low back pain |
ECM
|
Extracellular matrix |
Col II
|
Type II collagen |
Col I
|
Type I collagen |
MMPs
|
Metalloproteinases |
ER
|
Endoplasmic reticulum |
PRMPs
|
Pathogen-related molecular patterns |
DAMPs
|
Damage-related molecular patterns |
PRR
|
Pattern recognition receptor |
GSDMD
|
Gasdermin-D |
NPCs
|
Nucleus pulposus cells |
RIP
|
Receptor interacting protein |
STEAP3
|
Six-transmembrane epithelial antigen of prostate family member 3 |
SLC11A2/DMT1
|
Member 2 of solute carrier family 11 |
LIP
|
Labile iron pool |
FTH1
|
Ferritin heavy chain 1 |
FTL
|
Ferritin light chain |
FAs
|
Fatty acids |
LOOHs
|
Lipid hydroperoxides |
MDA
|
Malondialdehyde |
4HNE
|
4-hydroxynonenal |
PUFAs
|
Polyunsaturated FAs |
AA
|
Arachidonic acid |
PLs
|
Phospholipids |
LOX
|
lipoxygenase |
PE
|
Phosphatidylethanolamine |
PEBP1
|
Phosphatidylethanolamine binding protein 1 |
OMM
|
Outer membrane |
ACSL4
|
Acyl-CoA synthetase long-chain family 4 |
TZD
|
Thiazolidinediones |
ROSI
|
Rosiglitazone |
MUFAs
|
Monounsaturated FAs |
ACSL3
|
Acyl-CoA synthase long-chain family member 3 |
GSH
|
Glutathione |
SLC7A11
|
Solute carrier family 7 member 11 |
SLC3A2
|
Solute carrier family 3 member 2 |
GCL
|
Glutamate–cysteine ligase |
PLOH
|
Phosphatidylcholine |
TMZ
|
Temozolomide |
NAC
|
N-Acetylcysteine |
CoQ
|
Coenzyme Q |
MVA
|
Mevalonate |
IPP
|
Isopentenyl pyrophosphate |
GGPS
|
Pyrophosphate synthase |
SQS
|
Squalene synthase |
VDAC2/3
|
Voltage-dependent anion channel 2/3 |
GTP
|
Guanosine triphosphate |
GCH1
|
Guanosine triphosphate cyclic hydrolase 1 |
BH4
|
Tetrahydrobiotrexate |
DHFR
|
Dihydrofolate reductase |
NOX
|
NADPH oxidases |
DPP4
|
Dipeptidyl-peptidase 4 |
RTAs
|
Radical-trapping antioxidants |
Fer-1
|
Ferrostatin-1 |
Lip-1
|
Liproxstatin-1 |
α-TOH
|
Alpha-tocopherol |
DFO
|
Deferoxamine |
DFX
|
Deferasirox |
DFP
|
Deferiprone |
BHT
|
Butylated hydroxytoluene |
FPN
|
Ferroportin |
SLC40A1
|
Solute carrier family 40 member |
MTF1
|
Metal-regulated transcription factor 1 |
Hcy
|
Homocysteine |
CBS
|
Cystathionine β synthase |
ATF3
|
Activation transcription factor 3 |
SCI
|
Spinal cord injury |
HO-1
|
Heme oxygenase-1 |
G3BP1
|
Ras GTPase-activating protein-binding proteins 1 |
BACH1
|
BTB and CNC homology 1 |
USP11
|
Ubiquitin specific protease 11 |
CO
|
Carbon monoxide |
BV
|
Biliverdin |
BR
|
Bilirubin |
NPMSCs
|
NP-derived mesenchymal stem cells |
ncRNAs
|
Non-coding RNAs |
miRNAs
|
MicroRNAs |
lncRNAs
|
Long non-coding RNAs |
circRNAs
|
Circular RNAs |
Dnmts
|
DNA methyltransferase |
SAM
|
S-adenosine methionine |
EPC-EVs
|
Endothelial progenitor cells-secreted extracellular vesicles |
MALDI-TOF MS
|
Matrix-assisted laser desorption-ionization time of flight mass spectrometry |
SF
|
Serum ferritin |
SI
|
Serum iron |
TS
|
Transferrin saturation |
UIBC
|
Unsaturated iron binding capacity |
TIBC
|
Total iron binding capacity |