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. 2023 May 31;9(22):eadg3365. doi: 10.1126/sciadv.adg3365

Fig. 7. Effects of pPNP coating on anti-hematogenous infection.

Fig. 7.

(A) The study protocol of a prophylactic regimen with a hematogenous S. aureus implant infection mouse model. (B) Representative SEM images of biofilm formation on the implants harvested on day 14 after inoculation; n = 5 mice per group. Scale bar, 200 nm. (C) Gram staining of the bone tissues surrounding the implants. Blue arrows indicate scattered bacteria; n = 5 mice per group. Scale bar, 50 μm. (D) Euler diagram depicting the number of mice with or without infection in the surgical or nonsurgical legs of mice in the Ti or Ti-pPNP groups (n = 30 mice per group). (E) Representative fluorescent images showing the expression of OCN at the bone-implant interface (n = 5 mice per group). Scale bar, 100 μm. ***P < 0.001.