Table 2.
Results of the CSH regression model for 10-year incidence of DR (n = 23,531)
| Parameter | Crude CSH (95% CI) |
P | Adjusted CSH (95% CI) | P |
|---|---|---|---|---|
| Sex (M) | 1.07 (1.02, 1.12) | < 0.01** | 1.08 (1.03, 1.13) | < 0.001*** |
| DBP (mmHg) | 0.97 (0.94, 1.0) | 0.07 | 0.97 (0.94, 0.99) | < 0.05* |
| HbA1c (%) | 1.15 (1.11, 1.20) | < 0.001*** | 1.15 (1.11, 1.20) | < 0.001*** |
| HbA1c × NLR# | 0.94 (0.91, 0.97) | < 0.001*** | 0.94 (0.91, 0.97) | < 0.001*** |
| SBP (mmHg) | 1.05 (1.03, 1.06) | < 0.001*** | 1.05 (1.03, 1.06) | < 0.001*** |
| Age × NLR# | 0.99 (0.99, 1.0) | 0.30 | 0.99 (0.99, 0.99) | < 0.001*** |
| NLR (> 3.04) | 2.32 (1.21, 4.43) | < 0.05* | 1.63 (1.28, 2.07) | < 0.001*** |
| non-HDL-c (mmol/L) | 0.82 (0.75, 0.91) | < 0.001*** | 0.82 (0.75, 0.91) | < 0.001*** |
| BMI (kg/m2) | 0.95 (0.94, 0.97) | < 0.001*** | 0.95 (0.94, 0.97) | < 0.001*** |
| eGFR (ml/min/1.73 m2) | 1.03 (0.98, 1.08) | 0.19 | - | - |
| Diabetes drug (yes) | 1.11 (1.05, 1.17) | < 0.001 | 1.11 (1.06, 1.17) | < 0.001*** |
| Age (years) | 1.02 (0.98, 1.06) | 0.17 | - | - |
| eGFR × NLR# | 0.98 (0.94, 1.01) | 0.26 | - | - |
Variables labelled with # represent variable interaction terms with NLR (product term represented x symbol between variables). The effect estimates for eGFR, SBP and DBP are presented for a 10-unit increase whereas age and BMI were shown for a 5-unit increase. The same applies to the interaction terms of these variables with NLR in the multivariate regression models
CSH, Cause-specific hazard ratio
*p < 0.05; **p < 0.01; ***p < 0.001