Table 3.
Results of the FGR model for 10-year incidence of DR (n = 23,531)
| Parameter | Crude sHR (95% CI) |
P | Adjusted sHR (95% CI) | P |
|---|---|---|---|---|
| Sex (M) | 1.07 (1.02, 1.12) | < 0.01** | 1.05 (1.01, 1.10) | < 0.05* |
| DBP (mm Hg) | 0.98 (0.95, 1.01) | 0.22 | - | - |
| HbA1c (%) | 1.19 (1.15, 1.24) | < 0.001*** | 1.19 (1.15, 1.24) | < 0.001*** |
| HbA1c × NLR# | 0.93 (0.90, 0.96) | < 0.001*** | 0.94 (0.90, 0.96) | < 0.001*** |
| SBP (mmHg) | 1.00 (1.00, 1.01) | < 0.001*** | 1.08 (1.06, 1.09) | < 0.001*** |
| Age × NLR# | 0.97 (0.94, 1.00) | 0.05 | 0.98 (0.97, 0.98) | < 0.001*** |
| NLR (> 3.04) | 2.41 (1.27, 4.57) | < 0.01 | 2.24 (1.70, 2.94) | < 0.001*** |
| non-HDL-c (mmol/L) | 1.04 (0.95, 1.15) | 0.35 | - | - |
| BMI (kg/m2) | 0.99 (0.99, 0.99) | < 0.001*** | 0.93 (0.91, 0.94) | < 0.001*** |
| eGFR (ml/min/1.73 m2) | 0.96 (0.92, 1.01) | 0.16 | 0.97 (0.95, 0.98) | < 0.001*** |
| Diabetes drug (yes) | 1.01 (0.97, 1.07) | 0.45 | - | - |
| Age (years) | 1.01 (0.97, 1.04) | 0.60 | - | - |
| eGFR × NLR# | 1.00 (0.97, 1.04) | 0.80 | - | - |
Variables labelled with # represent variable interaction terms with NLR. The effect estimates for eGFR, SBP and DBP are presented for a 10-unit increase whereas age and BMI were shown for a 5-unit increase. The same applies to the interaction terms of these variables with NLR in the multivariate regression models (product term represented by × symbol between variables)
sHR, sub hazard ratio
*p < 0.05; **p < 0.01; ***p < 0.001