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. 2023 Jul 25;4(5):zqad038. doi: 10.1093/function/zqad038

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© The Author(s) 2023. Published by Oxford University Press on behalf of American Physiological Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Model predictions of redox ratios, , and RCI in response to sequential and increasing ADP additions to the heart and kidney cortex and OM mitochondria. Model predictions of mitochondrial (A–C) NADH ratio [C_NADH/(C_NADH + C_NAD)], (D–F) UQH₂ ratio [C_UQH2/(C_UQH2 + C_UQ)], (G–I) CytCred ratio [C_CytCred/(C_CytCred + C _CytCoxi)], (J–L) , and (M–O) RCI in the presence of 5 different substrate combinations including PM (5:2.5 m m), AM (5:2.5 m m), GM (5:2.5 m m), SUC (10 m m), and SUC + ROT (10 m m + 0.5 µm) in response to increasing ADP additions of 25, 50, 75, 100, 150, and 250 µm in the heart, kidney cortex, and kidney OM mitochondria. Some model simulations for SUC and SUC + ROT overlap in the kidney cortex and OM mitochondria (pink and cyan lines).

Inline graphic — Model predictions of redox ratios, , and RCI in response to sequential and increasing ADP additions to the heart and kidney cortex and OM mitochondria. Model predictions of mitochondrial (A–C) NADH ratio [C_NADH/(C_NADH + C_NAD)], (D–F) UQH₂ ratio [C_UQH2/(C_UQH2 + C_UQ)], (G–I) CytCred ratio [C_CytCred/(C_CytCred + C _CytCoxi)], (J–L) , and (M–O) RCI in the presence of 5 different substrate combinations including PM (5:2.5 m m), AM (5:2.5 m m), GM (5:2.5 m m), SUC (10 m m), and SUC + ROT (10 m m + 0.5 µm) in response to increasing ADP additions of 25, 50, 75, 100, 150, and 250 µm in the heart, kidney cortex, and kidney OM mitochondria. Some model simulations for SUC and SUC + ROT overlap in the kidney cortex and OM mitochondria (pink and cyan lines).