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. 2023 Jul 25;4(5):zqad038. doi: 10.1093/function/zqad038

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© The Author(s) 2023. Published by Oxford University Press on behalf of American Physiological Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Model predictions of redox ratios, , and RCI in response to increasing H⁺ leak in the heart and kidney cortex and OM mitochondria. Model predictions of mitochondrial (A–C) NADH ratio [C_NADH/(C_NADH + C_NAD)], (D–F) UQH₂ ratio [C_UQH2/(C_UQH2 + C_UQ)], (G–I) CytCred ratio [C_CytCred/(C_CytCred + C_CytCoxi)], (J–L) , and (M–O) RCI in the presence of 5 different substrate combinations including PM (5:2.5 m m), AM (5:2.5 m m), GM (5:2.5 m m), SUC (10 m m), and SUC + ROT (10 m m + 0.5 µm) in response to increasing H⁺ leak from 100% (control) to 900% at fixed ADP of 200 µm in the heart and ADP of 100 µm in the kidney cortex, and OM mitochondria. Some model simulations for SUC and SUC + ROT overlap in the kidney cortex and OM mitochondria (pink and cyan lines).

Inline graphic — Model predictions of redox ratios, , and RCI in response to increasing H⁺ leak in the heart and kidney cortex and OM mitochondria. Model predictions of mitochondrial (A–C) NADH ratio [C_NADH/(C_NADH + C_NAD)], (D–F) UQH₂ ratio [C_UQH2/(C_UQH2 + C_UQ)], (G–I) CytCred ratio [C_CytCred/(C_CytCred + C_CytCoxi)], (J–L) , and (M–O) RCI in the presence of 5 different substrate combinations including PM (5:2.5 m m), AM (5:2.5 m m), GM (5:2.5 m m), SUC (10 m m), and SUC + ROT (10 m m + 0.5 µm) in response to increasing H⁺ leak from 100% (control) to 900% at fixed ADP of 200 µm in the heart and ADP of 100 µm in the kidney cortex, and OM mitochondria. Some model simulations for SUC and SUC + ROT overlap in the kidney cortex and OM mitochondria (pink and cyan lines).