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. 2023 Jul 25;4(5):zqad038. doi: 10.1093/function/zqad038

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© The Author(s) 2023. Published by Oxford University Press on behalf of American Physiological Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Model predictions of key mitochondrial metabolites and with considerably different dynamics in the presence of SUC vs. SUC + ROT in the heart and kidney cortex and OM. Model simulations of the time courses of metabolite profiles including SUC (A–C), MAL (D–F), OXA (G–I), and Pi (J–L) in the mitochondrial matrix and across mitochondrial inner membrane (M–O) in the presence of SUC ± ROT (10 m m ± 0.5 µm) in response to sequential ADP additions of 25, 50, 75, 100, 150, and 250 µm in the heart and kidney cortex and OM mitochondria. The model predictions are done in the presence of 0.05 mg/mL mitochondrial for the heart and 0.2 mg/mL mitochondria for the kidney cortex and OM. Some model simulations for SUC and SUC + ROT overlap in the kidney cortex and OM mitochondria (pink and cyan lines).

Inline graphic — Model predictions of key mitochondrial metabolites and with considerably different dynamics in the presence of SUC vs. SUC + ROT in the heart and kidney cortex and OM. Model simulations of the time courses of metabolite profiles including SUC (A–C), MAL (D–F), OXA (G–I), and Pi (J–L) in the mitochondrial matrix and across mitochondrial inner membrane (M–O) in the presence of SUC ± ROT (10 m m ± 0.5 µm) in response to sequential ADP additions of 25, 50, 75, 100, 150, and 250 µm in the heart and kidney cortex and OM mitochondria. The model predictions are done in the presence of 0.05 mg/mL mitochondrial for the heart and 0.2 mg/mL mitochondria for the kidney cortex and OM. Some model simulations for SUC and SUC + ROT overlap in the kidney cortex and OM mitochondria (pink and cyan lines).