Table 2.
Correlations between gut microbiota and DN phenotypes.
| DN phenotypes | Positive correlation | Negative correlation | References |
|---|---|---|---|
| eGFR | Phylum level: Verrucomicrobia. Genus level: Lachnospiraceae_NC2004_group, Subdoligranulum | Genus level: Abiotrophia, Ruminococcus torques group. G_norank_f_Peptococcaceae | Tao et al. (2019), Chen W. H. et al. (2021), Zhang Q. et al. (2021) |
| SCR | Genus level: Abiotrophia. G_norank_f_Peptococcaceae | Genus level: Lachnospiraceae_NC2004_group, Parabacteroides. Species level: Clostridium sp. 26_22 | Tao et al. (2019), Zhang L. L. et al. (2022b), Zhang Q. et al. (2021) |
| UACR | Phylum level: Bacteroidetes, Elusimicrobia. Species level: Citrobacter farmer, Syntrophaceticus schinkii | Phylum level: Firmicutes, Bacteroidetes, Actinobacteria. Genus level: Bacteroides | Tao et al. (2019), Zhao et al. (2020), He et al. (2022) |
| 24-h UP | Genus level: Anaerosporobacter, Abiotrophia, Alistipes, Subdoligranulum | Genus level: Blautia | Li Y. et al. (2020), Chen W. H. et al. (2021), Zhang Q. et al. (2021) |
| HbA1c | / | Phylum level: Firmicutes. Genus level: Faecalibacterium, Lachnoclostridium, Roseburia. G_norank_f_norank_o_Oscillospirales, g_unclassified_f_Ruminococcaceae | Tao et al. (2019), Zhang Q. et al. (2021) |
| FBG | Genus level: Allobaculum | Phylum level: Firmicutes, Fusobacteria. Genus level: Fusobacterium | Tao et al. (2019), Li Y. et al. (2020) |
| BMI | Genus level: Escherichia–Shigella | / | Tao et al. (2019) |
| Blood lipids | Genus level: Bacteroides (TC), Lachnoclostridium (TC), Lachnoclostridium (TG), Bacteroides (TG), Parabacteroides (TG). Species level: Lachnospiraceae bacterium 3 1 46FAA (TC) | Species level: L. mucosae (LDL-C) | Chen W. H. et al. (2021), He et al. (2022), Zhang L. L. et al. (2022) |
| Tubular injury index | Phylum level: Bacteroidetes, Elusimicrobia | Phylum level: Firmicutes, Actinobacteria | Zhao et al. (2020) |
| Glomerularsclerosis | Phylum level: Elusimicrobia | / | Zhao et al. (2020) |
| Inflammatory cytokines | Genus level: Treponema (IL-6), Bacteroides (IL-6, NF-κB, TNF-α, IL-1β), Lactobacillus (IL-10) | Phylum level: Elusimicrobia (TNF-α). Genus level: Candidatus_Saccharimona (TNF-α), Ruminococcaceae UCG-005 (IL-1β), Christensenellaceae_R-7_group (IL-1β), Clostridiales_unclassified (IL-10), Megasphaera (IL-6) | Chen Q. et al. (2021), Chen W. H. et al. (2021), Su et al. (2022), Zhang M. et al. (2022), Zhao et al. (2020) |
| Oxidative stress factors | Genus level: Candidatus_Saccharimonas (MDA, GSH-Px), Ruminococcaceae UCG-005 (SOD), Allobaculum (SOD), Bacteroides (MDA), Christensenellaceae_R-7_group (SOD) | Genus level: Lactobacillus (MDA), Anaerovibrio (MDA), Bacteroides (SOD) | Su et al. (2022) |