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. Author manuscript; available in PMC: 2023 Dec 28.
Published in final edited form as: J Am Chem Soc. 2022 Dec 15;144(51):23685–23690. doi: 10.1021/jacs.2c11501

Scheme 2.

Scheme 2.

Derivatization reactions of 25. Reaction conditions: a) LiOH in MeOH, then HCl 1 M. b) LDA (2.2 equiv) and MeCN (2 equiv). c) Estrone (1 equiv), DMAP (0.05 equiv), DIC (1.2 equiv) in CH2Cl2. d) N,O-dimethylhydroxylamine (1 equiv), DMAP (0.05 equiv), DIC (1.2 equiv) in CH2Cl2. See Supporting Information for more details.