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. 2023 Apr 27;43(9):1475–1489. doi: 10.1177/0271678X231173187

Figure 5.

Figure 5.

CD 47 blocking antibody increased the number of giant cells and phagocytosis activity of microglia 3 days after intracerebral hemorrhage (ICH); (a) Representative hematoxylin and eosin stained image of giant cells engulfed red blood cells around the hematoma in ICH + IgG group and ICH+anti-CD47 group. Scale bar is 20 µm. (b) Representative image of GFP (green fluorescent protein; green) and F4/80 (red) double staining. * indicates F4/80(+)GFP(−) giant cells. # indicates F4/80(+)GFP(+) giant cells. Scale bar is 20 µm. (c) Quantification data on number of giant cells in perihematomal area. (d) Quantification data on percentage of F4/80(+)GFP(−) cell in giant cells in perihematomal area and (e) Quantification data on soma size of perihematomal F4/80(+)GFP(+) and F4/80(+)GFP(−) cells. *P < 0.05 vs the ICH + IgG group. Values are means ± SD; n = 6 per group.