TABLE 3.
Outcome of Propensity-matched Cohorts (<70 yr vs ≥70 yr)
| Statistic | <70 yr | ≥70 yr | P |
|---|---|---|---|
| Primary outcome | |||
| CLAD-free survival; % (95% CI) | 0.41 | ||
| 1 yr | 84.2 (72.5; 91.2) | 78.9 (66.9; 86.9) | — |
| 3 yr | 68.6 (55.2; 78.7) | 60.8 (47.1; 71.9) | — |
| 5 yr | 59.2 (44.6; 71.1) | 51.5 (37.3; 64.0) | — |
| Patient survival; % (95% CI) | 0.72 | ||
| 1 yr | 90.6 (80.3; 95.7) | 85.0 (73.9; 91.7) | — |
| 3 yr | 80.4 (68.1; 88.4) | 75.9 (63.1; 84.8) | — |
| 5 yr | 73.1 (58.9; 83.1) | 73.6 (60.2; 83.1) | — |
| PGD; n/N (%) | 0.85 | ||
| Any PGD-3 | 20/69 (28.99) | 18/69 (26.09) | — |
| No PGD-3 | 49/69 (71.01) | 51/69 (73.91) | — |
| Secondary outcome | |||
| Bronchoscopy; n/N (%) | 1.00 | ||
| Abnormal | 12/69 (17.39) | 13/69 (18.84) | — |
| Normal | 57/69 (82.61) | 56/69 (81.16) | — |
| ICU stay (d); median (IQR) | 6.0 (4.0–13.0) | 7.0 (4.0–12.0) | 0.46 |
| Hospital stay (d); median (IQR) | 29.0 (25.0–46.0) | 32.0 (23.5–51.0) | 0.10 |
| Reintervention; n/N (%) | 0.10 | ||
| No | 58/69 (84.06) | 49/69 (71.01) | — |
| Yes | 11/69 (15.94) | 20/69 (28.99) | — |
| Spirometry; median (IQR) | |||
| FEV1 (liter) | 0.25 | ||
| 3 yr | 2.35 (1.78–2.69) | 1.98 (1.76–2.70) | — |
| 5 yr | 2.22 (1.72–2.72) | 2.08 (1.60–2.30) | — |
| FVC (liter) | 0.79 | ||
| 3 yr | 2.92 (2.59–3.49) | 2.88 (2.47–3.63) | — |
| 5 yr | 2.72 (2.48–3.13) | 2.65 (2.38–3.03) | — |
| TLC (liter) | 0.88 | ||
| 3 yr | 4.66 (4.11–5.30) | 4.45 (3.93–5.63) | — |
| 5 yr | 4.47 (3.89–5.10) | 4.40 (3.93–4.84) | — |
| DLCO (mmol/min/kPa) | 0.16 | ||
| 3 yr | 4.32 (3.76–5.08) | 4.22 (3.30–4.98) | — |
| 5 yr | 4.15 (3.50–5.07) | 3.83 (3.05–4.87) | — |
| Time on ventilator (d); median (IQR) | 2.0 (1.0–5.0) | 2.0 (1.0–4.0) | 0.82 |
DLCO indicates diffusing capacity for carbon monoxide; FVC, forced vital capacity; IQR, interquartile range; TLC, total lung capacity.