Skip to main content
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1988 Apr;72(4):248–252. doi: 10.1136/bjo.72.4.248

Bilateral ocular disease as the initial presentation of malignant lymphoma.

R Weisenthal 1, W C Frayer 1, C W Nichols 1, R C Eagle 1
PMCID: PMC1041426  PMID: 3288277

Abstract

Malignant lymphocytic lymphoma rarely involves the eye. In two patients we found ocular signs and symptoms as the initial presentation of systemic disease. In the first patient periorbital swelling and ptosis of one year's duration ultimately proved to be the result of malignant lymphoma. After resolution of swelling and ptosis with chemotherapy, the patient returned with diffuse iris involvement and uveitis with a hypopyon. In the second patient an acute change of refractive error proved to be the result of a lymphomatous deposit in the choroid. In both instances common symptoms were the initial manifestations of a diffuse malignant disease.

Full text

PDF
248

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COOPER E. L., RIKER J. L. Malignant lymphoma of the uveal tract. Am J Ophthalmol. 1951 Aug;34(8):1153–1158. doi: 10.1016/0002-9394(51)90691-5. [DOI] [PubMed] [Google Scholar]
  2. Chambers J. D., Mosher M. L., Jr Intraocular involvement in systemic lymphoma. Surv Ophthalmol. 1966 Oct;11(5):562–564. [PubMed] [Google Scholar]
  3. Gass J. D., Sever R. J., Grizzard W. S., Clarkson J. G., Blumenkranz M., Wind C. A., Shugarman R. Multifocal pigment epithelial detachments by reticulum cell sarcoma. A characteristic funduscopic picture. Retina. 1984 Summer-Fall;4(3):135–143. doi: 10.1097/00006982-198400430-00001. [DOI] [PubMed] [Google Scholar]
  4. Knowles D. M., 2nd, Jakobiec F. A. Orbital lymphoid neoplasms: a clinicopathologic study of 60 patients. Cancer. 1980 Aug 1;46(3):576–589. doi: 10.1002/1097-0142(19800801)46:3<576::aid-cncr2820460326>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  5. Lewis R. A., Clark R. B. Infiltrative retinopathy in systemic lymphoma. Am J Ophthalmol. 1975 Jan;79(1):48–52. doi: 10.1016/0002-9394(75)90454-7. [DOI] [PubMed] [Google Scholar]
  6. Margolis L., Fraser R., Lichter A., Char D. H. The role of radiation therapy in the management of ocular reticulum cell sarcoma. Cancer. 1980 Feb 15;45(4):688–692. doi: 10.1002/1097-0142(19800215)45:4<688::aid-cncr2820450412>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  7. ROSENBERG S. A., DIAMOND H. D., JASLOWITZ B., CRAVER L. F. Lymphosarcoma: a review of 1269 cases. Medicine (Baltimore) 1961 Feb;40:31–84. doi: 10.1097/00005792-196102000-00002. [DOI] [PubMed] [Google Scholar]
  8. Simon J. W., Friedman A. H. Ocular reticulum cell sarcoma. Br J Ophthalmol. 1980 Oct;64(10):793–799. doi: 10.1136/bjo.64.10.793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Vogel M. H., Font R. L., Zimmerman L. E., Levine R. A. Reticulum cell sarcoma of the retina and uvea. Report of six cases and review of the literature. Am J Ophthalmol. 1968 Aug;66(2):205–215. doi: 10.1016/0002-9394(68)92065-5. [DOI] [PubMed] [Google Scholar]
  10. Yanoff M., Scheie H. G. Malignant lymphoma of the orbit--difficulties in diagnosis. Surv Ophthalmol. 1967 Apr;12(2):134–140. [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES